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High levels of NO can inhibit certain essential enzymes for example, it can interfere with how iron is incorporated into hemoglobin and how liver enzymes (cytochrome P450s) metabolize drugs
They also might suggest staying on a lower maintenance dose indefinitely
Encouragingly, technical progress has led to the development of multimolecular detection platforms, which may promote the development of early cancer detection and treatment monitoring by integrating EV biomarkers [118,119,120]
Combining complementary mechanisms theoretically offers additive metabolic benefits, but this remains largely evidence-based inference rather than proven clinical synergy in humans
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